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More about Dr. Yamanaka
Dr. Shinya Yamanaka is a Senior Investigator and the L.K. Whittier Foundation Investigator in Stem Cell Biology at the Gladstone Institute for Cardiovascular Disease (GICD). Dr. Yamanaka is also a Professor of Anatomy at the University of California, San Francisco, as well as the Director of the Center for iPS Cell
Research and Application (CiRA) and a Principal Investigator at the Institute for Integrated Cell-Material Sciences, both at Kyoto University.
Dr. Yamanaka’s research focuses on ways to generate cells resembling embryonic stem cells by reprogramming somatic, or skin, cells. He seeks to understand the molecular mechanisms that underlie pluripotency and the rapid proliferation of embryonic stem cells—they can become any type of cell in the body—and to identify the factors that induce reprogramming.
Dr. Yamanaka’s discovery that adult somatic cells can be reprogrammed into
pluripotent cells has had a profound effect on developmental and stem cell biology. By introducing the genes for four factors that turn genes on and off, he induced the skin cells of adult mice to become like embryonic stem cells, which he called induced pluripotent stem (iPS) cells. This iPS cell technology represents an entirely new platform for fundamental studies of developmental biology. Rather than using disease models made in yeast, flies, mice or other animals, iPS cells can be taken from patients with a specific disease. As a result, they contain a
complete set of the genes that resulted in that disease—representing the potential of an almost perfect disease model for studying disease development, new drugs and treatments.
In 1996, Dr. Yamanaka became an Assistant Professor at Osaka City University Medical School. In 1999, he was appointed Associate Professor at Nara Institute of Science and Technology, where he became a full professor in 2003. He took his current position as a professor at Kyoto University in 2004 and was appointed as a Senior Investigator at the Gladstone Institutes in 2007. Since 2008, he has directed CiRA.
Dr. Yamanaka has received many awards and honors, including the Albert Lasker Basic Medical Research Award, the Wolf Prize in Medicine, the Millennium Technology Award, the Shaw Prize, the Kyoto Prize for Advanced Technology, the Gairdner International Award, the Robert Koch Award and the March of Dimes Prize.
Dr. Yamanaka earned an MD from Kobe University in 1987 and a PhD from Osaka City University in 1993. From 1987 to 1989, he was a resident at the National Osaka Hospital. From 1993 to 1996, he was a postdoctoral fellow at GICD.
http://gladstoneinstitutes.org/scientist/yamanaka
更多关于山博士
山中伸弥博士是资深研究员和l k惠蒂尔基金会研究员在干细胞生物学Gladstone心血管疾病研究所(GICD)。山中博士也是一个解剖学教授在加州大学旧金山分校,以及中心的主任iPS细胞研究和应用程序(CiRA)和一个研究所的首席研究员综合测量科学,无论是在京都大学。 山中博士的研究主要集中在细胞的方法,为类似胚胎干细胞,重新编程体细胞,或皮肤,细胞。他试图理解分子背后机制和快速增殖的多能性可以成为胚胎干细胞细胞他们任何类型的细胞在身体和确定因素诱发重组。 山中博士的发现,成年体细胞可以重新编程到多能细胞产生了深刻的影响在发展和干细胞生物学。基因引入了四个因素,开启和关闭基因,他诱导皮肤细胞变成成年小鼠的胚胎干细胞,他被称为诱导多能干细胞(iPS细胞)。这个“诱导多能性”细胞技术是一种全新的平台的基本研究发育生物学。而不是使用疾病模型在酵母、果蝇、老鼠和其他动物,iPS细胞可能是来自于一个特定的疾病患者。因此,它们包含一组完整的基因,导致疾病代表一个几乎完美的潜在的疾病模型研究用于研究疾病发展,新的药物和治疗。
1996年,山中博士的助理教授成为大阪市立大学医学院。1999年,他被任命为助理教授奈良科学技术学院,在那里他成为了一名全职教授在2003年。他把他的当前位置,京都大学的教授在2004年和年被任命为高级调查员顿研究院在2007年。自2008年以来,他已经指示CiRA。
山中获得过许多奖项博士和荣誉,包括艾伯特·拉斯克基本医学研究奖,狼医学奖,年科技奖项,肖奖,《京都议定书》的奖的先进技术,Gairdner国际奖项,罗伯特?科赫奖和的March of Dimes慈善会奖。 山中获得一个博士从1987年神户大学医学博士和一个博士学位在1993年大阪市立大学。从1987年到1989年,他是一位居民在国家大阪医院。从1993年到1996年,他是一个GICD博士后研究员。